Christina Applegate reveals MS misdiagnosis in shocking health update: ‘I lost everything’
October 20, 2026
Christina Applegate shockingly revealed she was misdiagnosed with multiple sclerosis five years after receiving the diagnosis.
“[My doctor] came into my room and said, ‘Congratulations, you don’t have MS,’ ” Applegate recalled through tears on her MeSsy podcast Tuesday.
“I was, like, not happy at all. Everybody else was so happy.”

The actress explained that despite learning about the misdiagnoses, she still suffers from debilitating symptoms.
“You don’t get misdiagnosed and then all of the sudden I’m better,” Applegate continued. “I haven’t gotten better. If anything, I’ve gotten worse.”
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