PROGRAMMING NOTE: Watch the exclusive interview with second lady Usha Vance Wednesday on “Fox & Friends,” starting at 6am ET.

Second lady Usha Vance responded to what critics described as a “racist” dig from Michigan Democratic Senate nominee Abdul El-Sayed, who appeared to question how Vice President JD Vance’s grandfather would have regarded her.

The exchange began after Vance criticized El-Sayed’s views on Sharia law during a rally in Ohio, arguing the practice would be completely alien to his grandfather, whom he calls his “Papaw.”

“He once argued, not too long ago, that criticisms of Sharia law were rooted in White supremacy,” Vance said of El-Sayed, the American-born son of Muslim Egyptian immigrants.

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“I’d love to go back in time and tell my Papaw that there is a man who claims to stand for working people who says not only should we have Sharia law, but if you criticize it, you’re a White supremacist. That’s not my Papaw’s Democratic Party, my friends,” the vice president continued.

Responding to the vice president’s jab, El-Sayed wrote: “So do we think JD is taking Usha with him back in time to meet Papaw, or no…”

Critics interpreted the remark as an insinuation that Vance’s grandfather would not have accepted Usha because of her Indian heritage.

Michigan Senate candidate Abdul El-Sayed poses for a portrait in Grand Rapids, Michigan, on Feb. 21. (Evan Cobb for The Washington Post via Getty Images)

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“I have to admit, I kind of laughed,” Usha Vance told “Fox & Friends” in an exclusive interview set to air Wednesday morning.

“Because yes, I never met JD’s Mamaw and Papaw. But I do know and love the children that they raised, his mom, his aunt and uncle. And they have never been anything but incredibly loving.”

El-Sayed further addressed the comment in an interview on Saturday.

“The confusing thing about it is that he thinks that there are some people who are more American than others because they can point to their Papaw who was here earlier,” he told MS NOW. “And my question to him is simply: Why is it then, how do you look your parents-in-law in the eye and say that somehow they’re less American than you are? Because that’s what he’s implying there.”

Vice President JD Vance and second lady Usha Vance with their four children. (Second Lady Usha Vance @SLOTUS on X)

JD was raised in large part by his grandparents, James and Bonnie Vance, who he calls his “Papaw” and “Mamaw.” James died in 1997 and Bonnie died eight years later.

Usha and JD met while attending Yale Law School and married in 2014. Although she never met her husband’s late grandparents, the mother of four said her husband’s aunt has become a “second mother” to her.

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“His aunt is like a second mother to me,” said the second lady. “And so I have to think that if they raised children like that, they would have been loving as well. And I would have really, really, really loved to have met them.”

In his 2016 memoir, “Hillbilly Elegy,” Vance wrote that one of his “great regrets” was that his grandparents never had the opportunity to meet his wife.

El-Sayed’s campaign did not return Fox News Digital’s request for comment.