California Gov. Gavin Newsom called for invoking the 25th Amendment against President Donald Trump, calling the president “mentally ill” following Trump’s controversial remarks involving Los Angeles and San Diego.

“Donald Trump is mentally ill. TIME FOR THE 25TH!” Newsom said in statements provided to multiple media outlets.

The Democratic governor’s comments came after Trump referenced the two California cities while discussing Iran during a campaign rally in Grand Island, Nebraska, on Monday.

“They can take out a city. Let them take out Los Angeles. Let them take out San Diego,” Trump said. “This is a very small price to pay.”

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Newsom blasted the president as “deranged and dangerous” in a post on X responding to the remarks.

It is not the first time Newsom has called for using the 25th Amendment against Trump. In July, the California governor said Trump’s election integrity speech represented a “legitimate 25th Amendment moment” and described it as “the rambling of a mad king.”

That earlier call drew sharp pushback from Republicans, who accused Newsom and other Democrats of applying a double standard after defending former President Joe Biden amid questions about his age and cognitive fitness while he was in office.

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The 25th Amendment, ratified in 1967, provides a process under which the vice president and a majority of the Cabinet — or another body designated by Congress — can declare a president unable to discharge the powers and duties of the office.

U.S. President Donald Trump wraps up an appearance at a campaign rally at Pinnacle Bank Expo Center on the Nebraska State Fairgrounds on October 05, 2026 in Grand Island, Neb.

The White House has pushed back on interpretations of Trump’s latest comments, saying the president was arguing that American cities could have faced threats from Iran if Tehran had obtained a nuclear weapon.

White House communications director Steven Cheung said the ensuing “media freakout” was “not rooted in reality,” adding that Trump “was clearly stating U.S. cities would have been threatened if a nuclear Iran hadn’t been stopped.”

“America is safer because of the President. Iran has no nuclear, no navy, no air force, and no money,” Cheung said.

Gov. Gavin Newsom, D-Calif., and President Donald Trump shake hands on Jan. 24, 2025, in Los Angeles, California. (Mandel Ngan/AFP via Getty Images)

Trump’s remarks came as he discussed the costs associated with the conflict with Iran, telling the Nebraska crowd that Americans were paying a “small price … for keeping the world safe, keeping our country safe,” before referencing the potential threat to U.S. cities.

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Fox News Digital reached out to Newsom’s office and the White House, but did not immediately receive responses.