Justin Timberlake made a heartwarming appearance with his two sons, Silas and Phineas, to support his niece Zaya.

The singer attended the Global Down Syndrome Foundation’s annual fashion show, Be Beautiful Be Yourself, in Denver on Saturday for his 7-year-old niece, Zaya, who has Down syndrome. Timberlake held Zaya in his arms as he posed for red carpet pics alongside her parents, Rose and Justin Biel (Timberlake’s wife Jessica Biel’s younger brother).

Timberlake later walked the runway of the fashion show, where Silas and Phineas made a surprise appearance.

In video posted on social media, Timberlake, 45, adorably danced with Zaya in his arms as Silas, 11, also showed off some dance moves.

Phineas, 6, appeared to be the shyer of the two brothers, as he held himself close to his dad’s side.

Zaya was the clear star of the show, waving and blowing kisses as the crowd cheered.

In an Instagram Story the “Sexy Back” singer posted Sunday, he held both Phineas and Zaya’s hands on the runway, as Silas helped hold up Zaya’s other arm.

Phineas matched with his dad in a black suit, while Silas wore a leather jacket, black pants and sunglasses.

Timberlake captioned the sweet snap, “We walked my beautiful niece Zaya down the “@globaldownsyndrome runway last night,” with a red heart emoji.

He then shared a pic of him and Zaya smiling on the red carpet, writing, “proud uncle!”

Jessica, 44, was unable to attend this year’s event due to work commitments, the Global Down Syndrome Foundation shared in a press release. But her “7th Heaven” co-star and close friend Beverley Mitchell attended in support of the Biel family.

The event was a true success, raising a record-breaking $2.7 million to support research, medical care, and advocacy for people with Down syndrome.

The Timberlake family has been a longtime supporter of the annual event. Jessica walked the runway with Zaya at last year’s Be Beautiful Be Yourself fashion show in October 2025.

The “Texas Chainsaw Massacre” star also walked the nonprofit’s annual fashion show with her two sons in November 2024, when Zaya was named as the foundation’s ambassador.

She and the Grammy-winning musician have been married since October 2012.