Rosie O’Donnell went off on Megyn Kelly after the former Fox News host expressed outrage over Russell Brand’s 10-year prison sentence.

O’Donnell replied to comedian DL Hughley re-posting Kelly’s controversial comments on Threads Tuesday, in which the political commentator passionately argued that Brand’s sentence for one count of rape and three counts of sexual assault didn’t fit the crimes he was convicted of.

O’Donnell, 64, bluntly replied, “Go f–k urself Megan.”

This isn’t the first time O’Donnell has taken brutal shots at Kelly. In August, she Instagrammed a headline quoting Kelly claiming Dr. Anthony Fauci “hurt a lot more people” than the late convicted pedophile Jeffrey Epstein.

The “Harriet the Spy” star blasted Kelly in the caption, writing, “This dumb sycophant – woman hating witch 🧙‍♀️.”

On Monday’s episode of “The Megyn Kelly Show,” the host discussed Brand’s sentencing and incredulously asked, “Good Lord. Ten and a half years in prison?”

Kelly, 55, blasted the sentencing as “insane” and criticized UK policies, claiming the country allowed “immigrants” to come there and allegedly “rape young, white girls with impunity for years.”

“They did nothing for the vast majority of those child rapists,” she claimed. “And now Russell Brand — for grabbing boobs, kissing, sniffing and having that kind of sex with a woman who consented to vaginal sex with him seconds beforehand and also had clearly been joking with him and talking with him about having anal sex and had given him the equivalent on their first meeting for that — he’s going to jail for 10 years.”

She added, “This is an outrage. This is an obvious double standard.”

Brand, 51, was sentenced for his crimes — which took place between 1999 and 2009 — Monday after a month-long trial in London.

The father of three is currently being held at HMP Wandsworth, a prison plagued by overcrowding, vermin and violence, according to official watchdog reports.

A 2024 report by Wandsworth’s Independent Monitoring Board described conditions inside as “inhumane” and warned of severe risks caused by the overcrowding. For example, basic necessities were in short supply, with inmates sometimes going two or three weeks without a full change of clothing.

The report also found that crumbling floors provided access to vermin and that temperatures frequently topped 95 degrees Fahrenheit.

The Daily Mail reported Tuesday that Brand spent his first 24 hours in prison “staying in his cell as much as he can.”

The actor has been “trying not to show fear” according to the outlet, and has been “reading, meditating and praying for hours on end.”