Senate Republicans are projected to suffer yet another stunning setback, this time in reliably red Mississippi.

Incumbent Sen. Cindy Hyde-Smith, R-Miss., is projected to lose her bid for a second full term in the U.S. Senate to state District Attorney Scott Colom in a race, according to The Associated Press, that until the final weeks of October, was deadlocked.

More than a week after Election Day, the AP called the razor-thin race in favor of Colom on Wednesday, pushing the Democrats’ hold on the U.S. Senate to 55 seats to the Republicans’ 44 in another flip.

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President Donald Trump rallied behind her and a seven-figure, last-minute ad buy by the Senate Leadership Fund, a political action committee closely tied to Senate Majority Leader John Thune, R-S.D., were not enough to stop Colom’s momentum.

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U.S. Sen. Cindy-Hyde Smith, R-Miss., had eyed a second term in the upper chamber. (Al Drago/Bloomberg via Getty Images)

Her loss to Colom, who she previously blocked for a district court seat under the Biden administration years ago, comes after both parties rallied big names and resources in an effort to prevent a nightmare scenario for Republicans.

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