Dozens of cruise passengers were rushed to hospital Friday after a tanker “lost control” and slammed into the docked riverboat in New Orleans, leaving people floating in life jackets as others clung to the railings.

The Atlantic Asphalt tanker slammed into the docked American Cruise Lines’ American Heritage, which was carrying about 129 passengers as well as crew on the Mississippi River at around 12:30 p.m., Port NOLA told The Post.

Everyone aboard the paddlewheeler has been accounted for, New Orleans Mayor Helena Moreno said to cheers at a press conference.

Moreno said after the cruise ship was struck, passengers started to disembark – but the ship began sinking too quickly before they could all get off.

“Eventually the cruise ship toppled over and flipped. When that occurred, we started to have people in the water,” Moreno said.

Dramatic footage from the scene showed the cruise ship tilted sideways, with people in the treacherous water using life jackets and ring buoys to stay afloat.

“It was an all hands on deck approach” the mayor said of first responders.

The Coast Guard closed a three-mile stretch of the mighty Mississippi to all vessel traffic as crews rescued the people aboard and brought them inside the nearby port administration building for triage.

American Cruise Lines, which owns the sinking ship, told The Post that it remained “deeply concerned for everyone involved.”

Port NOLA press secretary Kimberly Curth said the immediate priority was the safety of passengers, crew members and first responders.